Asian Journal of Physics

Vol 32, Nos 9 – 12 (2023) 511-517

Development of cold atmospheric pressure plasma jet sources for biomedical application

Navin K Sharma¹, Priti Pal^2,3, Mahendra Singh², Vishali Singh², R Kumar², Alok Mishra²,
R P Lamba^2,3, Y Choyal¹ and Udit Narayan Pal^2,3
1School of Physics, Devi Ahilya Vishwavidyalaya, Indore-452 001, India
²CSIR-Central Electronics Engineering Research Institute, Pilani-333 031, India
³Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201 002, India
Dedicated to Prof B N Basu

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Characterization of dielectric barrier discharge (DBD) based cold atmospheric pressure plasma jet (C-APPJ) source has been carried out. The effects of the operating parameters have been analyzed on the effective formation and characteristics of the plasma plume. The emission spectra of the C-APPJ source have been measured to determine the presence of the reactive species generated from the developed sources. The discharge analysis and the plasma dynamics at higher flow rate of 3 SLM have been investigated. The discharge image shows that the plasma is emanated from the nozzle up to the distance of ~2.0 cm. The strongest spectral line centered around 308 nm shows the formation of the hydroxyl radical in the region of the plasma plume. A simulation has also been carried out to determine the velocity distribution of the gas at different flow rates in the C-APPJ source, and it was observed that the flow is turbulent in nature at higher gas flow rates (~3 SLM). The obtained results are expected to be useful for the design and development of C-APPJ sources for their potential utilisation in surface and biomedical applications. © Anita Publications. All rights reserved.
Keywords: Cold Plasma, Plasma Plume, Turbulence, Plasma medicine.

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Peer Review Information
Method: Single- anonymous; Screened for Plagiarism? Yes
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References

1. Punith N, Harsha R, Lakshminarayana R, Hemanth M, Anand M S, Dasappa S, Plasma Activated Water Generation and its Application in Agriculture, Adv Mater Lett, 10(2019)700–704.
2. Weltmann K D, von Woedtke T, “Plasma medicine—current state of research and medical application, Plasma Phys Control. Fusion, 59(2017)014031; doi:10.1088/0741-3335/59/1/014031.
3. Reuter S, von Woedtke T, Weltmann K D, The kINPen—a review on physics and chemistry of the atmospheric pressure plasma jet and its applications, J Phys D: Appl Phys, 51(2018)233001; doi.org/0.1088/1361-6463/aab3ad.
4. Dubey S K, Parab S, Alexander A,  Agrawal M, Achalla V P K, Pal U N,  Pandey M M, Kesharwani  P, Cold atmospheric plasma therapy in wound healing, Process Biochem, 112(2022)112–123.
5. Dubey S K, Dabholkar N, Pal U N, Singhvi G, Sharma N K, Puri A, Kesharwani P, Emerging innovations in cold plasma therapy against cancer: A paradigm shifts, Drug Discov. Today, 47(2022)2425–2439.
6. Bekeschus S, Schmidt A, Weltmann K D, von Woedtke T, The plasma jet kINPen – A powerful tool for wound healing, Clin Plas Med, 4(2016)19–28.
7. Sharma N K, Misra S, Varun, Lamba R P, Choyal Y, Pal U N, Analysis of Discharge Characteristics of Cold Atmospheric Pressure Plasma Jet, IEEE Trans Plasma Sci, 49(2021)2799–2805.
8. Nguyen D B, Mok Y S, Lee W G, Enhanced Atmospheric Pressure Plasma Jet Performance by an Alternative Dielectric Barrier Discharge Configuration, IEEE Trans Plasma Sci, 47(2019)4795–4801, doi.org/10.1109/TPS.2019.2896666.
9. Bekeschus S, Iséni S, Reuter S, Masur K, Weltmann K D, Nitrogen shielding of an argon plasma jet and its effects on human immune cells, IEEE Trans Plasma Sci, 43(2015)776–781.
10. Deepak G D, N K Joshi, Prakash R, Pal U N, Electrical characterization of argon and nitrogen based cold plasma jet, Eur Phys: J Appl Phys, 83(2018)20801; doi.org/10.1051/epjap/201818.
11. N K Sharma, Misra S, Varun, Pal U N, Experimental and simulation analysis of dielectric barrier discharge based pulsed cold atmospheric pressure plasma jet, Phys Plasmas, 27(2020)113502; doi.org/10.1063/5.0018901.
12. Iseni S, Laser diagnostics of an Ar atmospheric pressure plasma jet for biomedical applications, Ph D Thesis, Ernst-Moritz-Arndt, University of Greifswald, Greifswald, Germany, 2015.
13. Nastuta A V, Pohoata V, Topala I, Atmospheric pressure plasma jet—Living tissue interface: Electrical, optical, and spectral characterization, J Appl Phys,113(2013)183302, doi.org/10.1063/1.4804319.