Asian Journal of Physics Vol. 34, Nos 1 & 2 (2024) 9-21

Screening and management of type 2 diabetes mellitus with Raman spectroscopy

Kyra Grace Kaiser1 and Ioana Emilia Pavel1
1Department of Physical and Environmental Sciences, Texas A&M University Corpus Christi,
6300 Ocean Dr, Corpus Christi, TX 78412, U.S.A

Raman spectroscopy is a well-established analytical chemistry technique, which has proven to have numerous medical applications because of its chemical fingerprinting capabilities and compatibility with biological samples. Surface-enhanced Raman spectroscopy (SERS), an embodiment of Raman, has overcome many of the major limitations of normal Raman and has expanded its medical avenues due to its low detection limits. A growing application of Raman and SERS in clinical research focuses on the screening and management of type 2 diabetes mellitus (T2DM) to improve patient outcomes and quality of life. This review examines the Raman and SERS effects and outlines a few of their major applications (e.g., diagnosis, glucose measurement, biomarker detection, and pathogen identification) and current challenges (e.g., calibration for anatomical differences and inconsistencies of glucose levels in blood and interstitial fluids) within T2DM clinical studies. © Anita Publications. All rights reserved.
Doi: 
Keywords: Raman, SERS, Diabetes mellitus, Diagnostics, Biomarkers.

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