Hyperspectral imaging for skin cancer and blood disorders diagnosis

Meritxell Vilaseca¹, Francisco J Burgos-Fernández¹, Laura Rey-Barroso¹, Mónica Roldán^2,5,
Susanna Gassiot^3,5, Edurne Sarrate^3,5, Ignacio Isola^3,5 and Anna Ruiz Llobet^4
1Centre for Sensors, Instruments and Systems Development, Universitat Politècnica de Catalunya, Rambla de Sant Nebridi 11, 08222, Terrassa, Barcelona, Spain
²Unitat de Microscòpia Confocal i Imatge Cel•lular, Servei de Medicina Genètica i Molecular, Institut Pediàtric de Malalties Rares (IPER), Hospital Sant Joan de Déu, 08950, Esplugues de Llobregat, Barcelona, Spain.
³Laboratory of Hematology, Service of Laboratory Diagnosis / Institute of Pediatric Research, Hospital Sant Joan de Déu, Passeig Sant Joan de Déu 2, 08950, Esplugues de Llobregat, Spain
⁴Service of Pediatric Hematology, Hospital Sant Joan de Déu, Passeig Sant Joan de Déu 2, 08950, Esplugues de Llobregat, Spain 5Institut de Recerca Sant Joan de Déu, Santa Rosa 39-57, 08950, Esplugues de Llobregat, Barcelona, Spain

Dedicated to Prof Maria J Yzuel

Hyperspectral imaging is a novel technology for acquiring an image at a large number of wavelengths, thus allowing the study of spectral and spatial details of a sample under analysis. This technology has emerged as a promising imaging modality to be used as a diagnostic tool in several medical applications where spectral information is relevant. In this paper, we outline our most recent achievements in this field. Firstly, hyperspectral imaging systems developed to improve non-invasive diagnosis of skin cancer, consisting of digital silicon and InGaAs cameras and light emitting diodes, are described. Secondly, we present our latest study using hyperspectral technology together with confocal microscopy to improve the diagnosis of blood diseases, in particular, hemoglobinopathies such as thalassemia and cell membrane diseases such as hereditary spherocytosis. Finally, new insights on these topics are discussed. © Anita Publications. All rights reserved.
Keywords: Hyperspectral imaging, Confocal microscopy, Skin cancer, Hemoglobinopathies, Membrane protein defects.

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