An International Peer Reviewed Research Journal
Frequency : Monthly,
ISSN : 0971 – 3093
Editor-In-Chief (Hon.) :
Dr. V.K. Rastogi
e-mail:[email protected]
[email protected]

AJP ISSN : 0971 – 3093
Vol  15, No 1, January-March, 2006

Journal of Physics


Special Issue on Speckles in Medicine & Biology
Guest Edited By : Sergey S Ulyanov

Asian Journal of Physics
Vol. 15, No. 1 (2006)1-129
(An International Quarterly Research Journal of Physics)
(A Non-Profitable Registered Publication)




In viva investigation of human skin optical clearing and blood microcirculation under the action of glucose solution

Alexey N Bashkatov, Alexander N Korolevich, Valery V Tuchin, Yuri P Sinichkin, Elina A Genina, Mikhail M Stolnitz,

Nataly S Dubina, Sergey I Vecherinski and Michael S Belsley


Identification of artificial fingerprints using optical coherence tomography technique

Ravi Kiran Manapuram, Mohamad Ghosn and Kirill V Larin


Polarization correlometry of biological tissue speckle-images and diagnostics of their physiological state

Part I. Polarization cartography of biological tissue coherent images

O V Angelsky, A G Ushenko, Yu A Ushenko, Ye G Ushenko and Yu Ya Tomka 


Polarization correlometry of biological tissue speckle-images and diagnostics of their physiological state

Part II. Complex degree of mutual polarization (CDMP) of biological tissue speckle-images

O V Angelsky, A G Ushenko, Yu A Ushenko, Ye G Ushenko and Yu Ya Tomka


Polarization correlometry of biological tissue speckle-images and diagnostics of their physiological state

Part III. Polarization-correlation structure of speckle-images of biological tissues birefringent nets and their pathological changes diagnostics

O V Angelsky, A G Ushenko, Yu A Ushenko, Ye G Ushenko and Yu Ya Tomka


Comparison of glucose effect in model media and biological tissue measured using time-resolved optoacoustic method

Andrey A Bednov and Alexander A Oraevsky.


Laser speckle microscopic system for monitoring of dynamic blood perfusion

Dan Zhu, Qingming Luo, Ting Zhang, Haiying Cheng, Shaoqun Zeng and Sergey Ulyanov


Chronic tonsillitis: new approaches to the objective diagnosis by laser Doppler flowmetry

Gleb O Mareew, Oleg V Mareew, Galina N Maslyakova, Igor I Ivliev, Ivan V Fedosov, Valery V Tuchin and Vladislav V Lychagov


Flowmetry as method for diagnostics of microvascular resistance at essential hypertension

Vladimir F Lukyanov


Speckle dynamics produced by Lecithin-Water Sol-Gel transition

A P Vladimirov, N V Kilunova, A V Michurov and S V Yakovleva


Photoinactivation of bacteria of Francisella Tularensis by dynamic low-coherent speckles

Onega V Ulianova, Sergey S Ulyanov, Elena V Sazanova, Zhang Zhihong, Zhou Sibo, Qingming Luo,

Irina Zudina and Andrey Bednov


Development of the multiplayer phantoms for spectrofluorimetric studies

Svellana P Chernova and Alexander B Pravdin



Sergey S. Ulyanov

Sergey S. Ulyanov is professor of statistics and mathematics. His PhD, DSc and Dr habilit. dissertations have been dedicated to the questions of speckle dynamics with a small number of scatterers. He has taught graduate courses on statistical biomedical optics, speckle optics and courses on applied statistics at Saratov State University, Department of Optics and Biomedical Physics. He has been involved with the development of new methods of high-
resolution laser measurements at Institute of Precision Mechanics and Control of Russian Academy of Sciences for nearly 10 years. Ulyanov has authored more than 150 scientific papers. The field of research activity: speckle metrology, biomedical optics, speckle optics
and statistics. (For more details please visit the website



1986-1987 Engineer State Radiophysics and Electronics Institute “Wave”, Theoretical Department

1988 Researcher Institute of Precise Mechanics and Control of US SR Academy of Sciences

1989-1991 Scientific Fellow Institute of Precise Mechanics and Control
1992-1993 Senior Scientist Institute of Precise Mechanics and Control
1993-1996 Associate Professor of Saratov State University; Department of Optics and Biomedical Physics

1996-1997 Full Professor Department of Statistics and Mathematics, Saratov State University of Economics

1998-pres Full Professor of Saratov State University, Department of Optics and Biomedical Physics

Visiting Professor: Wroclaw Technical University (Poland) 1993; Riso National Laboratory (Denmark) 1995; Bang and Oluffsen (Denmark) 1995; University of Pennsylvania (USA) 1998; Wuhan University (China) 2000; Indian Institute of Technology (India) 2001, Microsoft Corporation (USA) 2002,


Instructor of SPIE Short Courses:

(1) High Resolution Speckle-Microscopy : Basic Physics and Applications

(2) Laser Speckle Metrology and Application



Speckle dynamics with a small number of scatterers, interference of dynamic speckle-fields, dynamics of statistically-inhomogeneous speckles, biospeckles statistics, wave propagation in highly scattering medium, Doppler effect with a small number scatterers, diffusing wave spectroscopy with a small number of scattering events, speckled speckles statistics.

Development of high-resolution scanning laser microscope, speckle interferometry of bioflow, laser diagnostics of blood microcirculation in oral cavity mucous membrane, blood and lymph flow measurements in narrow single capillaries.

 Guest Editorial

This special issue of Asian Journal of Physics is devoted to the recent achievements in the field of statistical optics with application to biomedical diagnostics. Recent decades, this branch of optics was developing very intensive.

This issue is exclusively focused on biospeckle dynamics, Doppler measurements, laser Doppler flowmetry, speckle microscopy, speckle-imaging techniques, specklesinphysiological optics, optical coherence tomography, optical. Doppler tomography, photonmigration in biotissues, image processing, light scattering within the dispersive biological media, diffusive optical imaging, light propagation in biological tissue, speckle photography, and laser-tissue interaction. Broadly speaking all aspects of speckle with application in medicine and biology is covered.

In particular, paper written by Alexey Bashkatov, et al. describes optical clearing of human skin and blood microcirculation controlled by administration of glucose solution. Laser Doppler flowmetry has been used for study of skin blood microcirculation under the action of the glucose solution. Results of the experiments demonstrated that at the action of the glucose solution blood perfusion and blood concentration increase, however the mean blood velocity does not change.

Paper by Ravi Manapuram et al. presents new approach to personal identification of fingerprints using optical coherence tomography. It is demonstrated that OCT could be a powerful tool for accurate and sensitive identification of the fingerprint gummies made from different materials.

Seria of papers of Oleg Angelsky et al is devoted to the questions of polarization correlometry of speckle-images, formed as a result of light scattering from biological tissue.

Polarization coordinate mapping, analysis of first-fourth orders statistics of biological tissues polarization azimuth and ellipticities, statistics of the complex degree of mutual polarization of biospeckle images and diagnostical possibilities of polarization-correlometry of speckle-images are the subjects of these papers.

New technique for characterization of glucose effect in biological tissue is discussed in the paper by Andrey Bednov and Alexander Oraevsky. Time-resolved optoacoustic method of monitoring the absorbed laser energy distribution in tissues was employed to measure changes in glucose concentration in phantoms and tissue in vitro.

            Dan Zhu and co-workers have suggested new system for monitoring of dynamic blood perfusion. Dynamic blood flow rate was measured with laser speckle microscopy by using techniques of zero-crossings. The developed method is expected to become a very useful for non-contacting and non-disturbing real-time monitoring of changes in the statement of blood microcirculation.

Paper of Gleb Mareew and co-workers describes new approaches to the objective diagnosis of chronic tonsillitis by laser Doppler flowmetry. Techniques, which are traditionally used by medical doctors, are painful and tonsil-destructive operation. LDF is free from these disadvantages. In this paper it is shown that the degree of sclerosis in tonsillar tissue affects the blood flow in tonsils.

In the paper of Vladimir F. Lukyanov, laser Doppler flowmetry is considered as method for diagnostics of microvascular resistance at hypertension. LDF was used to measure vasomotion and blood flow after arterial compression, decompression and venous hyperemia.

Peculiarities of speckle dynamics induced by lecithin-water sol-gel transition are studied in the paper of Alexander Vladimirov and co-authors. Designing the measuring equipment and developing the procedure for the analysis of the time dependent microscopic phenomena in biological systems are the purposes of this research.

Biochemical, biophysical and optical aspects of interaction of low-coherent light with bacterial cells have been investigated in the paper of Onega Ulianova and co-authors. Dynamic low-coherent speckles have been used for photoinactivation of bacteria, caused very dangerous disease, such as tularemia. Perspectives to the development of a principally new type of prophylactic medicine (including the vaccines against the extremely dangerous infections) based on the cellular suspensions treated with the dynamic speckle-fields are discussed.

Editor believes that in spite of a small collection of papers presented in this special issue this collection reflects the major directions of modern speckle optics for biology and medicine and will be useful for students and engineers involved in biomedical optics design and applications.


I wish to thank Professor Vinod Rastogi, Editor-in-Chief of Asian Journal of Physics for giving me the opportunity to edit this special issue ofAJP.


Special Issue Guest Editor


Sergey S. Ulyanov,

Professor of Department of Optics and Biomedical Physics,

Saratov State University, Russia,

Chief of Laboratory of Biomedical Optics,

Research-Educational Institute of Optics and Biophotonics, Russia.